Our work is revealing distinct subsets of eosinophils resident within the gastrointestinal tract that differentially promote health and tissue healing, or drive pathology.

Ongoing studies are: 1) defining surface receptor repertoires to distinguish “helpful” from “harmful” intestinal eosinophils; 2) deciphering the factors that shape eosinophil functional phenotypes; and 3) translating these new findings into developing novel therapeutic strategies to modulate eosinophil phenotypes in patients with eosinophil associated diseases.